P322 Lipid profiles in a Scottish adult cystic fibrosis (CF) centre - prevalence and significance in an aging population

To determine the prevalence of following cardiovascular (CV) risk factors; total cholesterol (C) >5, HDL C <1.1, Non-HDL >4, LDL >3, triglycerides >2.3 and total: >6. explore relationship between above factors age, gender, body mass index (BMI), CF diabetes (CFD), pancreatic transplant status. A blood lipid profile was collected, in a non-fasting state, at routine out-patient visits. 166 patients (90 men, 76 women). Median age 31 years. BMI 23.7 kg/m2. 34 (20.5%) sufficient (PS), 132 (79.5%) insufficient (PI). 13 (8%) post-transplant (Tx). 55 (33%) CFD. Tabled 1PrevalenceTotal >5 mmol/L (%)25 (15.1)HDL <1.1 (%)47 (28.3)Non-HDL >4 (%)16 (9.6)LDL >3 (9.6)Total: >6 (%)4 (2.4)Triglycerides (%)23 (13.9)RelationshipTotal mmol/LHDL mmol/LNon-HDL > 4 mmol/LTG's 2.3 mmol/LAge*Indicates statistically significant univariate 0.0021 level (Bonferroni correction). ns = non-significant*Indicates non-significantnsGendernsnsnsnsBMInsnsns*Indicates non-significantPI*Indicates non-significantns*Indicates non-significantnsTxnsnsnsnsCFDnsnsnsns* Indicates non-significant Open table new tab •Patients with 5 are significantly older less likely to be PI.•Patients younger.•Patients non-HDL TG’s have higher BMI.We demonstrated that considerable proportion our Scottish Adult an abnormal profile, which may increase CV risk. With advances treatment, prognosis is improving life expectancy increasing. This result increased dyslipidaemia disease.